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Pharmacology: Pharmacodynamics: Mechanism of action: Vinblastine is a cytotoxic drug that arrests cell growth at the metaphase. Its actions are more pronounced on the rapidly dividing cell than on the normal cell.
Pharmacokinetics: Distribution: Vinblastine is rapidly cleared from the blood and distributed into the body tissues. It crosses the blood-brain barrier poorly and does not appear in the CSF in therapeutic concentrations.
Metabolism: Vinblastine is extensively metabolised by the liver. It is converted to desacetyl-vinblastine which is more active on a weight basis than the parent compound.
Excretion: Vinblastine is excreted slowly in urine and in faeces via the bile.
